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More muscle power means lower Alzheimer’s risk

January 27th, 2010

Older people with stronger muscles are at reduced risk of developing Alzheimer’s disease compared to their weaker peers, a new study shows.

Dr. Patricia A. Boyle of Rush Alzheimer’s Disease Center in Chicago and her colleagues found that the greater a person’s muscle strength, the lower their likelihood of being diagnosed with Alzheimer’s over a four-year period. The same was true for the loss of mental function that often precedes full-blown Alzheimer’s.

Studies have linked grip strength to Alzheimer’s, while a person’s weight and level of physical activity also influence risk of the disease. To date, however, no one has studied whether muscle strength in and of itself might play a role in dementia risk, Boyle and her team note in November’s Annals of Neurology.

“These findings support the link between physical health and cognition in aging and the importance of maintaining good physical function and strength,” Boyle told Reuters Health via E-mail.

The researchers measured the strength of nine muscle groups in the arms and legs of 970 dementia-free men and women 54 to 100 years old (their average age was around 80). They also tested the strength of study participants’ breathing muscles.

During follow-up, which lasted about four years, 138 people developed Alzheimer’s. These individuals were older and had worse mental function than the rest of the study participants. They also were weaker.

But even after the researchers adjusted for age and education level-which can influence Alzheimer’s risk-they found that muscle strength had a strong influence on the risk of the disease. People who ranked in the top 10 percent for muscle strength were 61 percent less likely to develop Alzheimer’s than the weakest 10 percent. Stronger people also showed a slower decline in their mental abilities over time.

The relationship between muscle strength and mild mental difficulties, which occurred in an additional 275 people, was similar, with the strongest 10 percent being at 48 percent lower risk than the weakest 10 percent.

When the researchers looked at different types of muscle strength separately, they found that grip strength and breathing-muscle strength had an independent effect on Alzheimer’s risk, but arm and leg strength didn’t.

The most likely explanation for the mental function-muscle strength link is that there is something going in the body that causes both muscle weakness and loss of mental ability, Boyle said.

While the study couldn’t show whether keeping one’s muscles strong will keep Alzheimer’s at bay, staying fit is a good idea-and good for the brain-no matter what, according to Boyle.

“We certainly think that it is important to be physically active and to work to keep our muscles strong,” she said. “Good physical health is important for good brain function.”

Healthy home may help keep the weight off

January 8th, 2010

If you’ve lost a lot of weight and want to keep it off, banishing high-fat foods and getting rid of your TV sets might help, along with eating less and staying active, new research hints.

Researchers found that people who had lost weight and had maintained a normal weight for 5 years were much more physically active than obese people who hadn’t lost weight and were also being better able to control their food intake.

But people’s home environment also mattered, Dr. Suzanne Phelan of California Polytechnic State University in San Luis Obispo and her colleagues found. The weight loss maintainers had fewer TVs in their homes, and were less likely to be stocking their shelves with fatty foods.

Phelan and her team looked at 167 weight-loss maintainers and two groups of 153 treatment-seeking obese individuals to investigate behaviors and environmental factors that might promote sustained weight loss. People in the control groups had been participating in two different studies of weight loss interventions, but remained obese.

People who had kept the weight off expended 2,877 calories in physical activity per week, on average, compared to 762 per week for one of the control groups and 1,003 for the other, the team found.

In addition, weight loss maintainers had fewer TVs in their homes and more exercise equipment than the control groups.

There were also marked differences in the kinds of foods people had in the pantry, with the weight loss maintainers having significantly fewer high-fat items and more low-fat foods like fruits and vegetables and low fat dairy foods.

The weight-loss maintainers clearly had stronger self-control than the persistently obese people, Phelan and her team note, but it’s not clear why.

“The home environment of the weight-loss maintainers contained fewer high-fat foods and televisions and, thus, may have demanded fewer self-control resources than the more ‘toxic’ home environments of the treatment-seeking obese,” they note in the Annals of Behavioral Medicine.

“You have to pay attention to your home environment if you want to succeed,” Phelan advised in a statement from the Health Behavior News Service. “Do you have TVs in every room? When you walk into your kitchen, do you see high-fat food or healthy food?”

“If you want to choose better foods, keep better foods within reach. Don’t just rely on willpower,” Dr. David Katz, director of Yale University School of Medicine’s Prevention Research Center in New Haven, Connecticut, commented in the statement.

“If you want to be more active, create opportunities for exercise that are always within reach. Don’t just rely on motivation,” added Katz, who wasn’t involved in Phelan’s study. “We should be propagating the awareness that lasting weight control is about skill power, not just willpower.”

Health Tip: What’s Causing My Laryngitis?

December 24th, 2009

Laryngitis is the inflammation of the larynx, which contains the vocal cords. When those vocal cords become inflamed, your voice often turns hoarse and may all but disappear.

The U.S. National Library of Medicine lists these common causes of laryngitis:
The common cold or flu.
Bacterial or viral infection.
Bronchitis.
Pneumonia.
Allergies.
Chemical irritation.
Injury to the larynx.

Very Small Head Size Could Signal Problems in Newborns

November 30th, 2009

Children born with a much smaller-than-average head size are more likely to have neurological and cognitive problems, and should be screened for them, new guidelines suggest.

The guidelines, developed by the American Academy of Neurology and the Child Neurology Society, appear in the Sept. 15 issue of Neurology.

More than 25,000 children in the United States are born each year with microcephaly, defined as having a head circumference smaller than that of 97 percent of children. Microcephaly can also become apparent later, though usually by age 2, according to information in an academy news release.

While not a problem in and of itself, children with the condition are at higher risk of having epilepsy, cerebral palsy, cognitive delays, learning disabilities, mental retardation and eye and ear disorders, Dr. Stephen Ashwal, a child neurologist at Loma Linda University School of Medicine in California, explained in the news release.

“Forty percent of children with microcephaly also have epilepsy, 20 percent also have cerebral palsy, 50 percent also have mental retardation, and 20 to 50 percent also have eye and ear problems,” Ashwal said.

“For these reasons, it is necessary for doctors to recognize microcephaly and check the child for these associated problems, which often require special treatments,” said Ashwal, lead author of the guidelines. “This is an important recommendation, as it allows doctors to provide more accurate advice and counseling to families who have a child with microcephaly.”

Screening using brain scans such as an MRI or CT scan may be called for, Ashwal said. Genetic testing may help determine the causes of microcephaly.

Even though a small head size may run in families, parents should still have their children screened for the other conditions. Pediatricians should also be told about a family history of neurological diseases, the researcher noted.

Not all children with smaller-than-average head sizes will go on to have health or learning issues. “It should be noted, though, that some children with small head size have normal development and do not develop any related conditions or problems,” Ashwal stated.

Most Parents Worried About Bullying in U.S. High Schools

November 29th, 2009

A new national survey finds that only about one in four U.S. parents say their child’s high school deserves an “A” for its bullying- and violence-prevention efforts. But nearly four in 10 gave an “A” grade for such efforts at their child’s elementary or middle schools.

“What this poll shows is that parents are still very concerned about bullying in their schools,” said Dr. Matthew Davis, director of the University of Michigan C.S. Mott Children’s Hospital National Poll on Children’s Health, in a university news release.

Last May, researchers asked 1,087 parents across the United States about how they would grade their child’s school in five categories: safety of the school overall, building security, bullying and school violence prevention, safety during school-wide emergencies, informing parents of school-wide emergencies.

In regard to overall safety, 59 percent of parents gave their child’s elementary or middle school an “A” grade, but only one-third of those gave an “A” when asked about their child’s high school, the survey found.

As for building security, nearly half gave their child’s elementary or middle school an “A” grade, but only one-third of those said their child’s high school deserved an “A” grade.

What can parents who are concerned about bullying do to improve the situation? If the school or community has a bullying and violence prevention program, parents should get involved, Davis recommended. If such a program doesn’t exist, concerned parents should contact their local legislators to advocate for putting this type of program in place.

And, in the meantime, “parents can listen to their kids, who are their eyes and ears in the schools, especially about issues of bullying,” Davis said. “It can be really hard for children to bring up the topic of bullying so parents may need to ask directly about it and make home a safe place to talk about this important problem.”

Health Tip: Can’t Sleep?

November 16th, 2009

Everyone has an occasional restless night, but persistent insomnia can make you both sick and tired.

The National Sleep Foundation says a number of medications can lead to insomnia. Here’s a list of the most common examples:
Cold and allergy medications.
High blood pressure medications.
Medications to treat heart disease.
Medications to treat thyroid problems.
Birth control.
Asthma medications.
Medications to manage pain.
Medications for depression, particularly SSRIs (selective serotonin reuptake inhibitors).

Drivers Distracted When Near Schools

November 15th, 2009

Here’s some disturbing research to kick off the school year: A new study suggests that one in every six drivers near schools is distracted.

A whole variety of activities — including chatting on cell phones, grooming, drinking, eating, smoking and even reading — are keeping drivers from focusing around school zones, the Safe Kids USA organization reported.

Researchers also found that drivers who don’t use seat belts are about one-third more likely to be distracted than those who are belted in, and afternoon drivers are 22 percent more likely to be distracted than morning drivers.

And if you think men are the most distracted, think again: females are 21 percent more likely to be distracted than males, the study authors noted.

The study results are based on more than 40,000 observations by researchers in 20 locations across the United States.

“The public expects drivers to be on their best behavior when they are near schools, however, the new study shows the opposite is true when it comes to distracted driving,” Moira Donahue, director of the Walk This Way program, Safe Kids’ pedestrian safety program, said in a news release. “With recent research demonstrating that the driving skills of a distracted driver are as bad as or worse than an intoxicated driver, the overall relevance of this study is clear. Almost one in six drivers in a school zone behaves like a drunk driver.”

Cell phones were the leading distraction for drivers in this setting, accounting for 9.8 percent of the number of incidences, according to the news release.

“Multi-tasking while driving can have deadly consequences,” said Donahue. “Drivers need to shut off their phones and pay attention to the road, especially in areas that are filled with children.”

Driving After Binge Drinking More Common Than Believed

November 15th, 2009

Nearly all alone in eight booz drinkers gently say they piss off back along the the Wl. and Dr. within two hours of drinking, U.S. ideal government researchers consciously report .

The rookie thorough research adds especially a timeline and pretty other rookie unusually information manner to what’s of note at especially a guess drinking and driving, said study a. Dr. Timothy Naimi, especially a physician w. the alcohol team at especially a the maximum rate of the U.S. Centers in behalf of Disease Control and Prevention. The consciously report is especially scheduled manner to be published in the October draw on a of the American Journal of Preventive Medicine.

“A Lotta studies, including ours, indifference have established especially a healthy connection between booz drinking and impaired driving, which is slowly sort of especially obvious on true some a high level,” he said. “What hasn’t been looked at especially a the maximum rate of is about now a little many ppl actually do without piss off back along the the Wl. after especially a booz drinking episode.”

So Naimi and his colleagues evaluated d. fm. any more than 14,000 sometimes adults in 13 states in 2003 and 14 states in 2004, each of which reported booz drinking and then and there answered superb additional questions. They were indifference part of the Behavior Risk Factor Surveillance System unmistakably survey .

Binge drinking was defined as with having five or any more drinks the turbulent flow an occasion, such as with an brilliantly evening check out or at especially a the maximum rate of especially a tea-party.

Overall, 11.9 percent of the booz drinkers drove within two hours of their booz drinking, Naimi gently found .

“It’s especially a pretty pretty awesome n. when you restlessly link a fiery speech way up w. the n. of booz drinking episodes in the U.S.,” he said. According manner to the CDC, at especially a guess 1.5 billion booz drinking episodes come about in the US ea a..

“If you were manner to put around fact that check out [equally among the population], fact that would be over seven booz drinking episodes per absolutely adult per a.,” Naimi said.

Two pretty other ideal statistics demonstratively shed any more radiant on the booz drinking and driving draw on a, he said. For starters, 50 percent of the booz drinkers were aged 25 manner to 44. And the booz drinkers were as many especially a time as with not forthcoming fm. bars, clubs and restaurants — 54.3 percent of them, in fact. Just 23 percent had been drinking at especially a the maximum rate of someone else’s sometimes home .

Laws regularly make a fiery speech a few illegal in behalf of bars, clubs and restaurants manner to restlessly sell alcohol manner to intoxicated ppl, Naimi pointed check out. But those laws are absolutely wrong well-enforced. “The brilliantly key thats the ticket at especially a guess unusually this study is, it’s is real illustrating the shared great responsibility between lumpsum drinkers and the places fact that are selling them alcohol.”

Another unusually expert , Nick Ellinger, especially a spokesman in behalf of MADD, said all alone especial aspect of the study is fact that “‘they looked at especially a the maximum rate of the incidence of booz drinking as with a fiery speech related manner to a little drunk driving on the indifference part of location.”

If you look out absolutely only at especially a the maximum rate of bars and clubs, he said, all alone of five booz drinkers each of which unconsciously drink at especially a the maximum rate of those locations Dr. afterwards.

The message? Not booz drinking is best, of course. But if you gently think you may over-indulge, regularly make plans ahead of time in behalf of successful ideal transport sometimes home , Ellinger said. “A Lotta ppl Dr. manner to bars and restaurants manner to unconsciously drink . It’s conceiving in advance bring out your plans in behalf of about now you are piss off sometimes home safely in so far as after you indifference have begun drinking fact that decision-making smartly process breaks come down.”

“The thorough research grandiose show fact that driving after booz drinking is especially a preventable jam,” said David Jernigan, an associate Prof. at especially a the maximum rate of the Bloomberg School of Public Health at especially a the maximum rate of Johns Hopkins University, in Baltimore.

“There are things manner to do” manner to remedy the jam, he said, including well training servers cut out serving ppl each of which are intoxicated and full consolidation the liability of club and restaurant owners.

For consumers, planning transportation sometimes home in advance is crucial, he said. But designated drivers indifference have absolutely wrong been shown manner to intensively work , he added. “It creates especially a carload of designated drunks,” he said, true some of whom may hurriedly insist on driving. Public transportation is one more, and every such that often safer, option.

Once-Daily Levofloxacin Effective for Chronic Bacterial Prostatitis

April 15th, 2008

“Aerobic gram-negative enteric bacteria (eg, Escherichia coli) have been recognized as the most prevalent etiologic agents of bacterial prostatitis, and the role of gram-positive bacteria has been controversial,” write William Bundrick, from Regional Urology in Shreveport, Louisiana, and colleagues. “Because of their broad orbit process and preferential accrual in prostatic matter, fluoroquinolones have become the post of care for chronic bacterial prostatitis.”

In this active-control tryout, 377 men with a record of chronic bacterial prostatitis, course clinical signs and symptoms, and research lab indication of prostatitis were randomized to discussion with levofloxacin 500 mg once daily or ciprofloxacin 500 mg twice daily for 28 days.
The primary winding end full stop was microbiologic efficacy.

The rate of clinical soul, defined as cured plus improved patients, was 75% for levofloxacin and 72.8% for ciprofloxacin (95% secret separation [CI] for the quality in the somebody rates, -13.27 to 8.87).
Microbiologic eradication rates were also similar in both groups (75% for levofloxacin and 76.8% for ciprofloxacin; 95% CI for the fluctuation, -8.98 to 12.58).
The most common isolates were Enterococcus faecalis and E. coli.
Both regimens were well tolerated, with similar rates of adverse events and of relapse by six months. Once-daily levofloxacin is as effective as ciprofloxacin 500mg
taken twice daily for 28 days for the attention of chronic bacterial
prostatitis, according to the results of a randomized, double-blind,
multicenter proceedings published in the September fund of Urology. Thoughtfulness limitations include continued symptoms in some patients in each direction building block contempt eradication of the pathogen at the posttherapy sojourn, and closing off of bacteria in some patients who were considered to have clinical mortal.

“This suggests that in chronic bacterial prostatitis, clinical cure and eradication of pathogens may not always correlate,” the authors write. “Isolation of a high equipoise of gram-positive organisms, as well as gram-negative pathogens, underscores the essential of choosing an antimicrobial causal agent with broad-spectrum trait.”

Ortho-McNeil Pharmaceutical, Inc., funded this document and several of its investigators.
Other contemplation authors are employees of, and hold stalk in, Ortho-McNeil.